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etaracizumab/etaratuzumab/MEDI-522

DESCRIPTION CATALOG # SIZE PRICE
Anti-αVβ3 integrin Therapeutic Antibody (Abegrin) TAB-705 1mg Please Inquiry
Product Detail
Cat
TAB-705
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to human αVβ3 integrin. Etaracizumab is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer, ovarian cancer and various other types of cancer.
Target
αVβ3 integrin
Type
IgG2 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
CAS
892553-42-3
Trade name
abegrin
Molecular Weight
144.3 kDa
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Introduction
αVβ3 is a type of integrin that is a receptor for vitronectin.[1] It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore it is a receptor for phagocytosis on macrophages or dendritic cells.[2]

Inhibitors like etaracizumab may be used as antiangiogenics.
Antigen Description
integrin, beta 3.The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Keywords
αVβ3
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