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yttrium (90Y) tacatuzumab tetraxetan

DESCRIPTION CATALOG # SIZE PRICE
Anti-AFP Therapeutic Antibody (AFP-Cide) TAB-713 1mg Please Inquiry
Product Detail
Cat
TAB-713
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to human AFP. Yttrium (90Y) tacatuzumab tetraxetan is a humanized monoclonal antibody intended for the treatment of cancer. The antibody itself, tacatuzumab, is conjugated with tetraxetan, a chelator for yttrium-90, a radioisotope which destroys the tumour cells.
Target
AFP
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.
CAS
476413-07-7
Trade name
afp-cide
Molecular Weight
145 kDa
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Introduction
Yttrium (90Y) tacatuzumab tetraxetan is a humanized monoclonal antibody intended for the treatment of cancer.
Antigen Description
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Function
metal ion binding;
Gene ID
174
Synonyms
AFP; alpha-fetoprotein; HPAFP; FETA; alpha-fetoglobulin; alpha-1-fetoprotein;
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