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Panobacumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-B. anthracis anthrax protective antigen (PA) Therapeutic Antibody (Aerumab 11) TAB-105 1mg Please Inquiry
Product Detail
Cat
TAB-105
Product Overview
Recombinant monoclonal antibody to P. aeruginosa. Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against P. aeruginosa. It is a fully human pentameric IgM antibody with a mouse J chain.
Target
P. aeruginosa serotype IATS O11
Type
IgM - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
P. aeruginosa
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
885053-97-4
Trade name
aerumab 11
Specificity
Tested positive against native P. aeruginosa antigen
Protein Construction
immunoglobulin M-kappa [P. aeruginosa serotype IATS O11], Homo sapiens monoclonal antibody with a Mus musculus J chain
Predicted N terminal
H chain: EEQVVES; L chain: DVVMTQS
Molecular Weight
879900
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Introduction
This is a monoclonal antibody designed as an antibacterial against Pseudomonas aeruginosa. It is a fully human pentameric IgM antibody with a mouse J chain.
Antigen Description
P. aeruginosa is Gram-negative, aerobic, rod-shaped bacteria with unipolar motility. An opportunistic human pathogen, P. aeruginosa is also an opportunistic pathogen of plants. P. aeruginosa bacteria are clinically important because they are resistant to most antibiotics and they are capable of surviving in conditions that few other organisms can tolerate. Pseudomonas is often encountered in hospital and clinical work because it is a major cause of hospital acquired (nosocomal) infections. Its main targets are immunocompromised individuals, burn victims, and individuals on respirators or with indwelling catheters. Additionally, these pathogens colonize the lungs of cystic fibrosis patients. P. aeruginosa is often identified by its pearlescent appearance and grape-like odor in vitro. Definitive clinical identification of P. aeruginosa includes identifying the production of both pyocyanin and fluorescein as well as its ability to grow at 42°C. P. aeruginosa is capable of growth in diesel and jet fuel, where it is known as hydrocarbon utilizing microorganisms (or "HUM bugs"), causing microbial corrosion. It creates dark gellish mats sometimes improperly called "algae".
Keywords
Pseudomonas aeruginosa; P Aeruginosa; P. Aeruginosa; IATS O11
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