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actoxumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-C. difficile Toxin A Therapeutic Antibody TAB-716 1mg Please Inquiry
Product Detail
Cat
TAB-716
Product Overview
Recombinant human monoclonal antibody expressed in CHO binding to toxin A [C. difficile]. Actoxumab is a human monoclonal antibody designed for the prevention of recurrence of Clostridium difficileinfection.
Target
toxin A [C. difficile]
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
C. difficile
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.
CAS
1245634-25-6
Predicted N terminal
QVQLVESG
Molecular Weight
145.9 kDa
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Introduction
Clostridium difficile, or C. difficile, a gram positive anaerobic bacterium, is the major causative agent of colitis and diarrhoea that can occur following antibiotic intake. C. difficile infection is one of the most common hospital acquired infections. When C. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhoea and inflammation of the large intestine.
Antigen Description
Clostridium difficile, or C. difficile, a gram positive anaerobic bacterium, is the major causative agent of colitis and diarrhoea that can occur following antibiotic intake. C. difficile infection is one of the most common hospital acquired infections. When C. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhoea and inflammation of the large intestine.
Keywords
tcdA; toxA
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