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ocaratuzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-CD20 Therapeutic Antibody TAB-771 1mg Please Inquiry
Product Detail
Cat
TAB-771
Product Overview
Recombinant humanized antibody expressed in CHO binding to human MS4A1/CD20. Ocaratuzumab is a humanized monoclonal antibody designed for the treatment of cancer and autoimmune disorders. The antibody is engineered for enhanced affinity to the CD20 antigen on B-lymphocytes, increased antibody-dependent cell-mediated cytotoxicity (ADCC), and for improved treatment of low-affinity FcγRIIIa allotypes.
Target
MS4A1/CD20
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
1169956-08-4
Predicted N terminal
EVQLVQSG
Molecular Weight
145.3 kDa
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Introduction
Ocaratuzumab is a humanized monoclonal antibody designed for the treatment of cancer and autoimmune disorders.
Antigen Description
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Function
epidermal growth factor receptor binding;
Gene ID
931
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;
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