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milatuzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-CD74 Therapeutic Antibody TAB-763 1mg Please Inquiry
Product Detail
Cat
TAB-763
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD74. Milatuzumab is a monoclonal antibody for the treatment of multiple myeloma and other hematological malignancies.
Target
CD74
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
899796-83-9
Predicted N terminal
QVQLQQSG
Molecular Weight
146.7 kDa
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Introduction
Milatuzumab is a monoclonal antibody for the treatment of multiple myeloma and other hematological malignancies.
Antigen Description
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Function
MHC class II protein binding; MHC class II protein binding; beta-amyloid binding; cytokine binding; cytokine receptor activity; identical protein binding; nitric-oxide synthase binding;
Gene ID
972
Synonyms
CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen associated) , DHLAG; HLA class II histocompatibility antigen gamma chain; gamma chain of class II antigens; HLA DR gamma; Ia associated invariant chain; MHC HLA DR gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); II; DHLAG; HLADG; Ia-GAMMA; FLJ98970;
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