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dinutuximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-GD2 Therapeutic Antibody TAB-731 1mg Please Inquiry
Product Detail
Cat
TAB-731
Product Overview
Recombinant chimeric (human/Mouse) antibody expressed in CHO binding to human GD2. Dinutuximab is a chimeric monoclonal antibody that induces antibody dependent cell-mediated cytotoxicity. Dinutuximab is intended as maintenance therapy (targeting minimal residual disease) for high risk neuroblastoma, administered after induction therapy, autologous stem cell transplantation and/or radiotherapy.
Target
GD2
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
Predicted N terminal
EVQLLQSG
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Introduction
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. The relatively tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors.
Antigen Description
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans. The relatively tumor specific expression of GD2 makes it a suitable target for immunotherapy with monoclonal antibodies or with artificial T cell receptors.
Keywords
Disialoganglioside GD2; Ganglioside G2;GD2
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