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glembatumumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-GPNMB Therapeutic Antibody TAB-751 1mg Please Inquiry
Product Detail
Cat
TAB-751
Product Overview
Recombinant human monoclonal antibody expressed in CHO binding to human GPNMB. Glembatumumab vedotin is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB).
Target
GPNMB
Type
IgG2 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.
CAS
1020264-78-1
Predicted N terminal
QVQLQESG
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Introduction
Glembatumumab vedotin is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB).
Antigen Description
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Function
heparin binding; integrin binding;
Gene ID
10457
Synonyms
GPNMB; glycoprotein (transmembrane) nmb; transmembrane glycoprotein NMB; glycoprotein NMB; glycoprotein nmb like protein; HGFIN; NMB; osteoactivin; transmembrane glycoprotein; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN;
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