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Naptumomab estafenatox

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human 5T4 therapeutic Antibody Fab Fragment, 5T4 TAB-118-F(P) 1mg Please Inquiry
Product Detail
Cat
TAB-118-F(P)
Product Overview
Recombinant antibody Fragment Fab to 5T4. Naptumomab estafenatox (ABR-217620) is a drug for the treatment of various types of cancer like non-small cell lung carcinoma and renal cell carcinoma.
Target
5T4
Type
Fab - G1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
E.coli
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
676258-98-3
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin fragment, anti-[trophoblast glycoprotein (TPBG,5T4)] monoclonal 5T4 gamma1 heavy chain fragment fusion protein[Mus musculus VH (5T4V14: H41>P, S44>G, I69>T, V113>G)-IGHG1_CH1)] - [Glycyl-Glycyl-Prolyl] - superantigen SEA/E-120(synthetic), non-disulfide linked with monoclonal 5T4 kappa lightchain [Mus musculus V-KAPPA (5T4V18: F10>S, T45>K, I63>S,F73>L, T77>S, L78>V, L83>A)-IGKC]
Molecular Weight
73500
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60.
Gene ID
7162
Synonyms
TPBG; trophoblast glycoprotein; 5T4; 5T4 AG; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein; M6P1; 5T4AG;
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