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Crenezumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Abeta Therapeutic Antibody TAB-226 1mg Please Inquiry
Product Detail
Cat
TAB-226
Product Overview
Recombinant monoclonal antibody to Abeta. Crenezumab is a humanized monoclonal antibody against human 1-40 and 1-42 Beta amyloid, which is being investigated as a treatment of Alzheimer's disease.
Target
Abeta
Type
IgG4 - kappa
Immunogen
Pegylated beta-Amyloid Peptide
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
CAS
1174395-19-7
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G4, anti-(human 1-40- beta-amyloid/human 1-42- beta-amyloid) (human-mouse monoclonal MABT5102A heavy chain), disulfide with human-mouse monoclonal MABT5102A light chain, dimer
Predicted N terminal
H chain: EVQLVES; L chain: DIVMTQS
Molecular Weight
143330
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
Function
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; trans
Gene ID
351
Synonyms
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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