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Bapineuzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Abeta Therapeutic Antibody TAB-225 1mg Please Inquiry
Product Detail
Cat
TAB-225
Product Overview
Recombinant monoclonal antibody to Abeta. Bapineuzumab is a humanized monoclonal antibody that acts on the nervous system and may have potential therapeutic value for the treatment of Alzheimer's disease and possibly glaucoma.
Target
Abeta
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
CAS
648895-38-9
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human beta-amyloid) (human-mouse monoclonal heavy chain), disulfide with human-mouse monoclonal light chain, dimer
Molecular Weight
148800
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
Function
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; trans
Gene ID
351
Synonyms
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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