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Ponezumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Abeta Therapeutic Antibody TAB-227 1mg Please Inquiry
Product Detail
Cat
TAB-227
Product Overview
Recombinant monoclonal antibody to Abeta. Ponezumab is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.
Target
Abeta
Type
IgG2 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
CAS
1178862-65-1
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G2, anti-(human beta-amyloid) (human-mouse monoclonal PF-04360365 clone 9TL heavy chain), disulfide with human-mouse monoclonal PF-04360365 clone 9TL light chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: DVVMTQS
Molecular Weight
148270
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
Function
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; trans
Gene ID
351
Synonyms
APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;
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