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Belimumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human BLys Therapeutic Antibody (Benlysta, LymphoStat-B) TAB-030 1mg Please Inquiry
Product Detail
Cat
TAB-030
Product Overview
Recombinant monoclonal antibody to Human BLyS. Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE).
Target
BLyS
Type
IgG1 - lambda
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
CAS
356547-88-1
Trade name
benlysta, lymphostat-b
Specificity
Tested positive against native human antigen
Protein Construction
ImmunoglobulinG1, anti-(human cytokine BAFF) (human monoclonal LymphoStat-B heavy chain),disulfide with human monoclonal LymphoStat-B l-chain, dimer
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Function
cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding;
Gene ID
10673
Synonyms
TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; TNFSF20; tumor necrosis factor ligand superfamily member 13B; BAFF; BLYS; CD257; TALL 1; TALL1; THANK; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20; DTL; ZTNF4; TALL-1;
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