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Abagovomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CA-125 Therapeutic Antibody TAB-114 1mg Please Inquiry
Product Detail
Cat
TAB-114
Product Overview
Recombinant monoclonal antibody to CA-125. Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.
Target
CA 125
Type
IgG1 - kappa
Immunogen
CA-125 purified from human ovarian carcinoma.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
CAS
792921-10-9
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1,anti-(mouse OC 125) (mouse monoclonal ACA-125 clone 3D5 g-chain), disulfide with mousemonoclonal ACA-125 clone 3D5 k-chain, dimer
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
CA 125 (cancer antigen 125) is a tumour marker or biomarker that may be elevated in the blood of some people with specific types of cancers. CA 125 is a mucinous glycoprotein and the product of the MUC16 gene. It is best known as a marker for ovarian cancer, but it may also be elevated in other malignant cancers.
Function
protein binding;
Gene ID
94025
Synonyms
MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;
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