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Mogamulizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CCR4 Therapeutic Antibody TAB-187 1mg Please Inquiry
Product Detail
Cat
TAB-187
Product Overview
Recombinant monoclonal antibody to CCR4. Mogamulizumab (USAN; trade name Poteligeo) is a humanized monoclonal antibody targeting CC chemokine receptor 4 (CCR4). It has been approved in Japan for the treatment of relapsed or refractory adult T-cell leukemia/lymphoma.
Target
CCR4
Type
IgG1 - kappa
Immunogen
KLH conjugate CCR4 partial peptide
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
1159266-37-1
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human C-C chemokine receptor type 4); humanized mouse monoclonal KW-0761 γ1 heavy chain (222-219")-disulfide with humanized mouse monoclonal KW-0761 kappa light chain, dimer (228-228"":231-231"")- bisdisulfide
Predicted N terminal
H chain: EVQLVES; L chain: DIVMTQS
Molecular Weight
146440
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Antigen Description
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Function
C-C chemokine receptor activity; G-protein coupled receptor activity; chemokine receptor activity; receptor activity; signal transducer activity;
Gene ID
1233
Synonyms
CCR4; chemokine (C-C motif) receptor 4; C-C chemokine receptor type 4; CC CKR 4; CD194; ChemR13; CKR4; CMKBR4; k5 5; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4; K5-5; CC-CKR-4; HGCN:14099; MGC88293;
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