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Anti-Human CCR5 Therapeutic Antibody

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CCR5 Therapeutic Antibody TAB-895 1mg Please Inquiry
Product Detail
Cat
TAB-895
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to human CCR5. Anti-Human CCR5 Therapeutic Antibody is a humanized monoclonal antibody targeted against the CCR5 receptor found on T lymphocytes of the human immune system. It is being investigated as a potential therapy in the treatment of HIV infection.
Target
CCR5
Type
IgG4
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Introduction
Anti-Human CCR5 Therapeutic Antibody is a humanized monoclonal antibody targeted against the CCR5 receptor found on T lymphocytes of the human immune system. It is being investigated as a potential therapy in the treatment of HIV infection.
Antigen Description
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Function
C-C chemokine binding; C-C chemokine receptor activity; C-C chemokine receptor activity; G-protein coupled receptor activity; actin binding; chemokine (C-C motif) ligand 5 binding; chemokine receptor activity; coreceptor activity; phosphatidylinositol pho
Gene ID
1234
Synonyms
CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine (C C motif) receptor 5 , CMKBR5; C-C chemokine receptor type 5; CC CKR 5; CD195; CKR 5; CKR5; IDDM22; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; CCR-5; CKR-5; CCCKR5; CMKBR5; CC-CKR-5; FLJ78003;
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