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Efalizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD11A Therapeutic Antibody (Raptiva) TAB-024 1mg Please Inquiry
Product Detail
Cat
TAB-024
Product Overview
Recombinant monoclonal antibody to Human CD11A. Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis. As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection. Efalizumab binds to the CD11a subunit of lymphocyte function-associated antigen 1 and acts as an immunosuppressant by inhibiting lymphocyte activation and cell migration out of blood vessels into tissues. Efalizumab was associated with fatal brain infections and was withdrawn from the market in 2009.
Target
CD11A
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, WB and most other immunological methods.
CAS
214745-43-4
Trade name
raptiva
Specificity
Tested positive against native human antigen
Predicted N terminal
H Chain: EVQLVESL Chain: DIQMTQS
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Function
Cell adhesion molecule binding; Protein heterodimerization activity; Receptor activity
Gene ID
3683
Synonyms
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; integrin alpha-L; LFA 1; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; LFA-1; LFA1A
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