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Erlizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD18 therapeutic Antibody F(ab')2 fragment TAB-154-F(E) 1mg Please Inquiry
Product Detail
Cat
TAB-154-F(E)
Product Overview
Recombinant antibody Fragment F(ab')2 to CD18. Erlizumab, also known as rhuMAb, is a recombinant humanized monoclonal antibody that was an experimental immunosuppressive drug. Erlizumab treats heart attack, stroke, and traumatic shock.
Target
CD18
Type
IgG1
Immunogen
Tissue / cell preparation (Human). (Leucocytes of a patient suffering from a LGL-type leukaemia).
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
CAS
211323-03-4
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-[human integrin beta2] F[ab"]2 fragment [human-mouse monoclonal γ1-chain], disulfide with human-mouse monoclonal light chain, dimeralpha
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
Function
binding; glycoprotein binding; protein kinase binding; receptor activity;
Gene ID
3689
Synonyms
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); CD18, integrin, beta 2 (antigen CD18 (p95), lymphocyte function associated antigen 1; macrophage antigen 1 (mac 1) beta subunit) , MFI7; integrin beta-2; LFA 1; MAC 1; integrin beta chain, beta 2; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1;
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