Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

Siplizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD2 Therapeutic Antibody TAB-104 1mg Please Inquiry
Product Detail
Cat
TAB-104
Product Overview
Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
Target
CD2
Type
IgG1 - kappa
Immunogen
Human CD2 recombinant protein
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
CAS
288392-69-8
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1,anti-(human CD2 (antigen)) (human-rat monoclonal MEDI-507 g1-chain), disulfide withhuman-rat monoclonal MEDI-507 light chain, dimer
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Function
eukaryotic cell surface binding; protein binding; protein homodimerization activity; receptor activity; receptor activity;
Gene ID
914
Synonyms
CD2; CD2 molecule; CD2 antigen (p50), sheep red blood cell receptor , SRBC; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor; T11; SRBC; LFA-2; FLJ46032;
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-097-1828


© 2007 - 2017 Creative-Biolabs All Rights Reserved