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Ofatumumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD20 Therapeutic Antibody (Arzerra) TAB-028 1mg Please Inquiry
Product Detail
Cat
TAB-028
Product Overview
Recombinant monoclonal antibody to Human CD20. Ofatumumab (trade name Arzerra, also known as HuMax-CD20) is a human monoclonal antibody (for the CD20 protein) which appears to inhibit early-stage B lymphocyte activation. It is FDA approved for treating chronic lymphocytic leukemia that is refractory to fludarabine and alemtuzumab (Campath) and has also shown potential in treating Follicular non-Hodgkin's lymphoma, Diffuse large B cell lymphoma, rheumatoid arthritis and relapsing remitting multiple sclerosis. Ofatumumab has also received conditional approval in Europe for the treatment of refractory chronic lymphocytic leukemia. This makes ofatumumab the first marketing application for an antibody, as well as the first human monoclonal antibody which targets the CD20 molecule that will be available for patients with refractory CLL.
Target
CD20
Type
IgG1 - kappa
Immunogen
Hmuan CD20 transfected NS/O cells.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
679818-59-8
Trade name
arzerra
Specificity
Tested positive against native human antigen
Predicted N terminal
H Chain: MFLGLSWL Chain: MEAPAQL
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
CD20 is B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.
Function
epidermal growth factor receptor binding;
Gene ID
931
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;
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