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Rituximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD20 Therapeutic Antibody (rituximab) TAB-016 1mg Please Inquiry
Product Detail
Cat
TAB-016
Product Overview
Recombinant monoclonal antibody to Human CD20. Rituximab (trade names rituximab and rituximab) is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B cells (this should not be confused with pancreatic β- or beta cells). Rituximab destroys B cells and is therefore used to treat diseases which are characterized by excessive numbers of B cells, overactive B cells, or dysfunctional B cells. This includes many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
Target
CD20
Type
IgG1 - kappa
Immunogen
Human lymphoblastoid cell line SB
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, WB and most other immunological methods.
CAS
174722-31-7
Trade name
rituximab
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1,anti-(human CD20 (antigen)) (human-mouse monoclonal C2B8 gamma 1-chain), disulfide with human-mouse monoclonal C2B8 kappa-chain, dimer
Predicted N terminal
H Chain: QVQLQQPL Chain: QIVLSQS
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
CD20 is B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.
Function
epidermal growth factor receptor binding;
Gene ID
931
Synonyms
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;
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