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varlilumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD27 Therapeutic Antibody TAB-H74 1mg Please Inquiry
Product Detail
Cat
TAB-H74
Product Overview
Recombinant human antibody to Human CD27. Varlilumab is an immunotherapy designed to enhance the body's natural immune response by directly activating T cells that can specifically recognize and kill cancer cells.
Type
IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
Specificity
CD27 (TNFRSF7, tumor necrosis factor receptor superfamily member 7) [Homo sapiens]
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Background
Antigen Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor
Function
cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; receptor activity; transmembrane signaling receptor activity;
Gene ID
939
Synonyms
CD27; CD27 molecule; TNFRSF7, tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14; TNFRSF7; MGC20393;
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