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Teplizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD3 Therapeutic Antibody TAB-159 1mg Please Inquiry
Product Detail
Cat
TAB-159
Product Overview
Recombinant monoclonal antibody to CD3. Teplizumab is a monoclonal antibody which is used as an immunosuppressive drug. Teplizumab is a humanized Fc-engineered monoclonal antibody also known as MGA031 and hOKT3γ1(Ala-Ala).
Target
CD3
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
876387-05-2
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human CD3 (antigen) ε-chain) (human-mouse monoclonal MGA031 heavy chain), disulfide with human-mouse monoclonal MGA031 light-chain, dimer
Predicted N terminal
H chain: QVQLVQS; L chain: DIQMTQS
Molecular Weight
145800
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
Function
protein heterodimerization activity; receptor activity; transcription coactivator activity; transmembrane signaling receptor activity;
Gene ID
915
Synonyms
CD3D; CD3d molecule, delta (CD3-TCR complex); CD3d antigen, delta polypeptide (TiT3 complex) , T3D; T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex); T3D; CD3-DELTA;
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