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Foralumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD3 epsilon Therapeutic Antibody TAB-245 1mg Please Inquiry
Product Detail
Cat
TAB-245
Product Overview
Recombinant monoclonal antibody to CD3 epsilon. Foralumab is an immunomodulator. It binds to CD3 epsilon.
Target
CD3 epsilon
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, IP, IF, FuncS, FC, Neut, ELISA and most other immunological methods.
CAS
946415-64-1
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens CD3E (CD3epsilon)], Homo sapiens monoclonal antibody;gamma1 heavy chain (1-448) [Homo sapiens VH (IGHV3-33*01(95.90%) -(IGHD)-IGHJ2*01) [8.8.11] (1-118) -IGHG1*03 CH2L1.3>A, L1.2>E (119-448)], (221-215")-disulfide withkappa light chain (1"-215") [Homo sapiens V-KAPPA (IGKV3-11*01(100.00%) -IGKJ4*01) [6.3.10] (1"-108") -IGKC*01 (109"-215")]; (227-227"":230-230"")-bisdisulfide dimer
Predicted N terminal
H chain: QVQLVES; L chain: EIVLTQS
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Function
SH3 domain binding; T cell receptor binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor signaling complex scaffold activity; receptor signaling protein activity; transmembrane signaling receptor activity;
Gene ID
916
Synonyms
CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit of T3; T3E; TCRE; FLJ18683;
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