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Gemtuzumab ozogamicin

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD33 Therapeutic Antibody Fab fragment (Mylotarg) TAB-013 1mg Please Inquiry
Product Detail
Cat
TAB-013
Product Overview
Recombinant antibody fragment Fab to Human CD33. Gemtuzumab ozogamicin is a drug-linked monoclonal antibody (an antibody-drug conjugate) that was used to treat acute myelogenous leukemia from 2000-2010.
Gemtuzumab is a monoclonal antibody to CD33 linked to a cytotoxic agent from the class of calicheamicins. CD33 is expressed in most leukemic blast cells but also in normal hematopoietic cells, the intensity diminishing with maturation of stem cells.
Target
CD33
Type
IgG4 kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.
CAS
220578-59-6
Trade name
mylotarg
Specificity
Tested positive against native human antigen
Protein Construction
ImmunoglobulinG4 (anti-(human CD33 (antigen)) (human-mouse monoclonal hP67.6 gamma 4-chain)),disulfide with human-mouse monoclonal hP67.6 kappa-chain, dimer
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Function
receptor activity; sugar binding;
Gene ID
945
Synonyms
CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3;
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