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catumaxomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD3E Therapeutic Antibody (REMOVAB) TAB-H13 1mg Please Inquiry
Product Detail
Cat
TAB-H13
Product Overview
Recombinant Rat antibody to Human CD3E. Catumaxomab (trade name Removab) is a rat-mouse hybrid monoclonal antibody which is used to treat malignant ascites, a condition occurring in patients with metastasizing cancer. It binds to antigens CD3 and EpCAM.
Type
IgG2a - kappa / G2b - lambda
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.
CAS
509077-98-9
Trade name
removab
Specificity
CD3E (CD3 epsilon) [Homo sapiens] ;
Protein Construction
immunoglobulin G2a, anti-(human antigen 17-1A) (mouse monoclonal Ho-3/TP-A-01/TPBs01 heavy chain), disulfide with mouse monoclonalHo-3/TP-Bi specific, trifunctional antibody.A-01/TPBs01 light chain, disulfide with immunoglobulin G2b anti-(human CD3 (antigen)) (rat monoclonal 26/II/6-1.2/TPBs01 heavy chain), bidisulfide with rat monoclonal 26/II/6-1.2/TPBs01 light chain
Purity
>95.0% as determined by analysis by RP-HPLC.
Background
Antigen Description
CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.
Function
SH3 domain binding; T cell receptor binding; protein heterodimerization activity; protein kinase binding; receptor activity; receptor signaling complex scaffold activity; receptor signaling protein activity; transmembrane signaling receptor activity;
Gene ID
916
Synonyms
CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit of T3; T3E; TCRE; FLJ18683;
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