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Ruplizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD40L Therapeutic Antibody (Antova) TAB-027 1mg Please Inquiry
Product Detail
Cat
TAB-027
Product Overview
Recombinant monoclonal antibody to Human CD40L. Ruplizumab (trade name Antova) is a humanized monoclonal antibody intended for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis. A study showed that the drug was associated with life-threatening thromboembolisms, while another study only found thrombocytopenia.
Target
CD40L
Type
IgG1 - kappa
Immunogen
Animals were immunized with D1.1 cells.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
CAS
220651-94-5
Trade name
antova
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1,(anti-human CD40 ligand) (human-mouse monoclonal 5c8 gamma 1-chain), disulfide with human-mouse monoclonal 5c8 kappa-chain, dimer
Predicted N terminal
H Chain: QVQLVQSL Chain: DIVLTQS
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Antigen Description
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Function
CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding;
Gene ID
959
Synonyms
CD40LG; CD40 ligand; HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome); CD40 antigen ligand; CD40L; CD154; gp39; hCD40L; hyper IgM syndrome; T B cell activating molecule; TNF related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; CD40-L; T-cell antigen Gp39; T-B cell-activating molecule; TNF-related activation protein; IGM; IMD3; HIGM1; T-BAM; TNFSF5;
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