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Zolimomab aritox

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD5 Therapeutic Antibody TAB-884 1mg Please Inquiry
Product Detail
Cat
TAB-884
Product Overview
Recombinant mouse monoclonal antibody scFv fragment expressed in E. Coli binding to human CD5. Zolimomab aritox is a mouse monoclonal antibody which has been investigated for the treatment of systemic lupus erythematosus and graft-versus-host disease, but the studies failed to show positive effects of the drug.It is an anti-CD5 antibody which is linked to the A chain of the ricin protein.
Target
CD5
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
CAS
141483-72-9
Predicted N terminal
MPMGSLQP
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Introduction
Zolimomab aritox is a mouse monoclonal antibody which has been investigated for the treatment of systemic lupus erythematosus and graft-versus-host disease, but the studies failed to show positive effects of the drug.It is an anti-CD5 antibody which is linked to the A chain of the ricin protein.
Antigen Description
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
Function
glycoprotein binding; protein binding; receptor activity; scavenger receptor activity; transmembrane signaling receptor activity;
Gene ID
921
Synonyms
CD5; CD5 molecule; CD5 antigen (p56 62) , LEU1; T-cell surface glycoprotein CD5; T1; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; LEU1;
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