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Itolizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD6 Therapeutic Antibody TAB-247 1mg Please Inquiry
Product Detail
Cat
TAB-247
Product Overview
Recombinant monoclonal antibody to CD6. Itolizumab (INN, trade name Alzumab) is a 'first in class' humanized IgG1 monoclonal antibody. It selectively targets CD6, a pan T cell marker involved in co-stimulation, adhesion and maturation of T cells. Itolizumab, by binding to CD6, down regulates T cell activation, causes reduction in synthesis of pro-inflammatory cytokines and possibly plays an important role by reducing T cell infiltration at sites of inflammation. A double blind, placebo controlled, phase III treat –Plaq study of itolizumab successfully met the pre-specified primary end-point of significant improvement in PASI-75 (Psoriasis Area and Severity Index) score after 12 weeks of treatment in patients with moderate to severe psoriasis compared to placebo.
Target
CD6
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
CAS
1116433-11-4
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens CD6 (Tp120, T12)],humanized monoclonal antibody;gamma1 heavy chain (1-449) [humanized VH (Homo sapiensIGHV3-21*08 (83.70%) -(IGHD)-IGHJ5*01) [8.8.12] (1-119) -Homosapiens IGHG1*01 (120-449)], (222-214")-disulfide with kappa lightchain (1"-214") [humanized V-KAPPA (Homo sapiens IGKV1-17*01(76.80%) -IGKJ2*01 F118>L, Q120>S) [6.3.9] (1"-107") -Homosapiens IGKC*01 (108"-214")]; (228-228"":231-231"")-bisdisulfidedimer
Predicted N terminal
H chain: EVQLVES; L chain: DIQMTQS
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
Function
scavenger receptor activity;
Gene ID
923
Synonyms
CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171;
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