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altumomab pentetate

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CEA Therapeutic Antibody (Hybri-ceaker) TAB-H03 1mg Please Inquiry
Product Detail
Cat
TAB-H03
Product Overview
Recombinant Mouse antibody to Human CEA. Indium (111In) altumomab pentetate (INN) (USP, indium In 111 altumomab pentetate; trade name Hybri-ceaker) is a mouse monoclonal antibody linked to pentetate which acts as a chelating agent for the radioisotope indium-111. The drug is used for the diagnosis of colorectal cancer
Type
IgG
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, IHC and most other immunological methods.
CAS
156586-92-4
Trade name
hybri-ceaker
Protein Construction
Indium (111In) labeled
Purity
>95.0% as determined by analysis by SDS-PAGE.
Background
Introduction
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEA stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEA is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.
Keywords
CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP; BGP1; BGPI; antigen CD66; CD66a antigen; CEACAM3; carcinoembryonic antigen-related cell adhesion molecule 3; CEA; CGM1; Carcinoembryonic antigen
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