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Arcitumomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CEA therapeutic Antibody Fab Fragment (CEA-Scan) TAB-014-F(E) 1mg Please Inquiry
Product Detail
Cat
TAB-014-F(E)
Product Overview
Recombinant monoclonal antibody Fragment Fab to Human CEA. Technetium (99mTc) arcitumomab is a drug used for the diagnostic imaging of colorectal cancers. It consists of the Fab' fragment of a monoclonal antibody (arcitumomab, trade name CEA-Scan) and a radionuclide, technetium-99m. Technetium (99mTc) arcitumomab is an immunoconjugate. Arcitumomab is a Fab' fragment of IMMU-4, a murine IgG1 monoclonal antibody extracted from the ascites of mice. The enzyme pepsin cleaves the F(ab')2 fragment off the antibody. From this, the Fab' fragment is prepared by mild reduction. Before application, arcitumomab is reconstituted with a solution of the radioactive agent sodium pertechnetate (99mTc) from a technetium generator.
Target
CEA
Type
Fab' - G1
Immunogen
Full length native protein (CEA)
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
154361-48-5
Trade name
cea-scan
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1, anti-(human carcinoembryonic antigen) Fab fragment (mouse monoclonal gamma 1-chain), disulfide with mouse monoclonal light chain
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced in gastrointestinal tissue during fetal development, but the production of CEA stops before birth. Therefore, it is usually present only at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers. CEA is a glycosyl phosphatidyl inositol (GPI) cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.
Function
molecular_function; protein binding;
Gene ID
634
Synonyms
CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); BGP; carcinoembryonic antigen-related cell adhesion molecule 1; BGP1; CD66a; antigen CD66; CD66a antigen; BGPI;
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