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Mavrilimumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CSF2RA Therapeutic Antibody TAB-096 1mg Please Inquiry
Product Detail
Cat
TAB-096
Product Overview
Recombinant monoclonal antibody to CSF2RA. Mavrilimumab is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
Target
CSF2RA
Type
IgG4 - lambda2
Immunogen
Human GM-CSF Receptor alpha transfected COS cells.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
1085337-57-0
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G4-lambda, anti-[Homo sapiens CSF2RA (granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, CD116)], Homo sapiens monoclonal antibody;gamma4 heavy chain (1-447) [Homo sapiens VH (IGHV1-24*01 (93.80%) -(IGHD)-IGHJ3*02) [8.8.13] (1-120) -IGHG4*01 (121-447)], (134-216")-disulfide with lambda light chain (1"-217") [Homo sapiens V-LAMBDA (IGLV1-40*01 (87.90%) -IGLJ2*01) [9.3.11] (1"-111") -IGLC2*01 (112"-217")]; (226-226"":229-229"")-bisdisulfide dimer
Predicted N terminal
H Chain: QVQLVQS; L Chain: QSVLTQP
Molecular Weight
143200
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Function
cytokine receptor activity; receptor activity;
Gene ID
1438
Synonyms
CSF2RA; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CSF2R; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; CD116; GMR-alpha; GMCSFR-alpha; CD116 antigen; GM-CSF receptor alpha subunit; colony stimulating factor 2 receptor alpha subunit; granulocyte-macrophage colony-stimulating factor receptor alpha chain; GMR; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; MGC3848; MGC4838; GM-CSF-R-alpha;
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