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Cetuximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human EGFR Therapeutic Antibody (Erbitux) TAB-003 1mg Please Inquiry
Product Detail
Cat
TAB-003
Product Overview
Recombinant monoclonal antibody to Human EGFR. Cetuximab (Erbitux) is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion.
Target
EGFR
Type
IgG1 - kappa
Immunogen
CHO cells transfected with a plasmid bearing a truncated form of EGFR cDNA
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, IHC and most other immunological methods.
CAS
205923-56-4
Trade name
erbitux
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 g1-chain),disulfide with human-mouse monoclonal C225 kappa-chain, dimer
Predicted N terminal
H chain: QVQLKQSL chain: DILLTQS
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Background
Antigen Description
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
Function
ATP binding; MAPK/ERK kinase kinase activity; actin filament binding; double-stranded DNA binding; enzyme binding; epidermal growth factor-activated receptor activity; epidermal growth factor-activated receptor activity; identical protein binding; contrib
Gene ID
1956
Synonyms
EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61;
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