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Panitumumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human EGFR Therapeutic Antibody (Vectibix) TAB-020 1mg Please Inquiry
Product Detail
Cat
TAB-020
Product Overview
Recombinant monoclonal antibody to Human EGFR. Panitumumab (INN), formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans).
Target
EGFR
Type
IgG2 - kappa
Immunogen
EGFR expressed on the surface of cells (A431 cells)
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, Neut, IF, WB, ELISA, IP, FC, WB and most other immunological methods.
CAS
339177-26-3
Trade name
vectibix
Specificity
Tested positive against native human antigen
Protein Construction
Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal heavy chain), disulfide with human monoclonal light chain, dimer
Predicted N terminal
H chain: TITCQASL chain: VSGGSIS
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
Function
ATP binding; MAPK/ERK kinase kinase activity; actin filament binding; double-stranded DNA binding; enzyme binding; epidermal growth factor-activated receptor activity; epidermal growth factor-activated receptor activity; identical protein binding; contrib
Gene ID
1956
Synonyms
EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61;
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