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Adecatumumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human EPCAM Therapeutic Antibody TAB-106 1mg Please Inquiry
Product Detail
Cat
TAB-106
Product Overview
Recombinant monoclonal antibody to EpCAM. which is used to target tumor cells. It binds to the epithelial cell adhesion molecule (EpCAM - CD326). Adecatumumab has been used in clinical studies of treatment in prostate and breast cancers.
Target
EpCAM
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
503605-66-1
Specificity
Tested positive against native human antigen.
Protein Construction
immunoglobulin G1, anti-(human antigen 17-1A) (human monoclonal MT201 γ1-chain), disulfide with human monoclonal MT201 kappa-chain, dimer
Predicted N terminal
H chain: EVQLLES; L chain: ELQMTQS
Molecular Weight
147500
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Size
1mg
Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Background
Antigen Description
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Function
protein binding;
Gene ID
4072
Synonyms
EPCAM; epithelial cell adhesion molecule; antigen identified by monoclonal AUA1 , M4S1, MIC18, TACSTD1, tumor associated calcium signal transducer 1; 17 1A; 323/A3; CD326; CO 17A; EGP 2; EGP34; EGP40; Ep CAM; ESA; GA733 2; HEA125; KS1/4; KSA; Ly74; MH99; MK 1; MOC31; TACST 1; TROP1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); M4S1; MK-1; DIAR5; EGP-2; MIC18; EGP314; HNPCC8; TACSTD1; GA733-2;
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