Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

trastuzumab emtansine

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ERBB2 Therapeutic Antibody (trastuzumab emtansine) TAB-H70 1mg Please Inquiry
Product Detail
Cat
TAB-H70
Product Overview
Recombinant Humanized (from mouse) antibody to Human ERBB2. Trastuzumab emtansine (ado-trastuzumab emtansine, trade name trastuzumab emtansine) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (trastuzumab) linked to the cytotoxic agent mertansine (DM1). Trastuzumab alone stops growth of cancer cells by binding to the HER2/neu receptor, whereas mertansine enters cells and destroys them by binding to tubulin. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the toxin specifically to tumor cells. The conjugate is abbreviated T-DM1.
Target
ERBB2
Type
IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
1018448-65-1
Trade name
trastuzumab emtansine
Specificity
ERBB2(epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340) [Homo sapiens]
Protein Construction
immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, HER-2, p185c-erbB2, NEU, EGFR2)], humanizedmonoclonal antibody conjugated to maytansinoid DM1;gamma1 heavy chain (1-449) [humanized VH (Homo sapiens IGHV3-66*01 (81.60%) – (IGHD) – IGHJ6*01 T123>L) [8.8.13] (1-120) – Homo sapiensIGHG1*03 (121-449) CH1 R120>K], (223-214')- disulfide with kappa light chain (1'-214') [humanized V-KAPPA (Homo sapiens IGKV1-39*01 (86.30%) – IGKJ1*01) [6.3.9] (1'-107') – Homo sapiens IGKC*01(108'-214')]; (229-229":232-232")- bisdisulfide dimer;conjugated, on an average of 3 to 4 lysyl, to maytansinoid DM1 via a succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC)linker
Purity
>95.0% as determined by analysis by RP-HPLC.
Background
Antigen Description
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human) is a protein that in humans is encoded by the ERBB2 gene, which is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu.
Function
ATP binding; ErbB-3 class receptor binding; Hsp90 protein binding; RNA polymerase I core binding; epidermal growth factor-activated receptor activity; glycoprotein binding; contributes_to growth factor binding; identical protein binding; nucleotide bindin
Gene ID
2064
Synonyms
ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; HER2; NEU; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); NGL; TKR1; HER-2; MLN 19; HER-2/neu;
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-097-1828


© 2007 - 2017 Creative-Biolabs All Rights Reserved