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duligotumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ERBB3 Therapeutic Antibody TAB-H21 1mg Please Inquiry
Product Detail
Cat
TAB-H21
Product Overview
Recombinant human antibody to Human ERBB3. Duligotumab (INN) is a human monoclonal antibody designed for the treatment of cancer. It acts as an immunomodulator and binds to HER3
Type
IgG
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
CAS
1314238-96-4
Protein Construction
Patents refer to a Bispecific antibody Her3 / EGFR but duligotumab is described as solely anti-Her3 in INN entrygamma1 heavy chain (1-451) [Homo sapiens VH (IGHV3-74*01 (82.70%) – (IGHD) – IGHJ4*01) [8.8.14] (1-121) – IGHG1*03 CH1 R120>K (218) (122-451)], (224-214') – disulfide withkappa light chain (1'-214') [Homo sapiens V- KAPPA (IGKV1- 39*01 (87.40%) – IGKJ2*01 L124>V (104)) [6.3.9] (1'-107') – IGKC*01 (108'-214')];(230-230'':233-233'') – bisdisulfide dimer"Anti-HER3/EGFR, a dual action antibody, is a phage-derived, human IgG1 monoclonal antibody that is designed to target human epidermal growthfactor receptor 3 (HER3) and epidermal growth factor receptor (EGFR)." – Roche pipeline
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Background
Antigen Description
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
Function
ATP binding; growth factor binding; growth factor binding; nucleotide binding; protein binding; protein heterodimerization activity; protein heterodimerization activity; protein homodimerization activity; protein tyrosine kinase activator activity; NOT pr
Gene ID
2065
Synonyms
ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
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