Follow us on:
Dedication / Services
To provide 50000 services and products to global scientific research units every year

Edrecolomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human EpCAM/17-1A Therapeutic Antibody (Panorex) TAB-701 1mg Please Inquiry
Product Detail
Cat
TAB-701
Product Overview
Recombinant mouse monoclonal antibody expressed in Sp2/0 mouse myeloma cells binding to human EpCAM/17-1A. Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A, which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma. However, when put to a phase III study it did not provide any benefit when compared to conventional chemotherapeutic agents. Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer.
Target
EpCAM/17-1A
Type
IgG2a - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
Sp2/0 mouse myeloma cells
Applications
Suitable for use in ELISA, IP, FC, FuncS, IF, Neut and most other immunological methods.
CAS
156586-89-9
Trade name
panorex
Molecular Weight
Approximately 150 kDa
Purity
>95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Introduction
Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A.
Antigen Description
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Function
protein binding;
Gene ID
4072
Synonyms
EPCAM; epithelial cell adhesion molecule; antigen identified by monoclonal AUA1 , M4S1, MIC18, TACSTD1, tumor associated calcium signal transducer 1; 17 1A; 323/A3; CD326; CO 17A; EGP 2; EGP34; EGP40; Ep CAM; ESA; GA733 2; HEA125; KS1/4; KSA; Ly74; MH99; MK 1; MOC31; TACST 1; TROP1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); M4S1; MK-1; DIAR5; EGP-2; MIC18; EGP314; HNPCC8; TACSTD1; GA733-2;
Download Datasheet:

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Online Inquiry
Please input "biolabs"(case insensitive) as verification code.
Loading...
Contact Us

USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email: 

Europe
Tel: 44-207-097-1828


© 2007 - 2017 Creative-Biolabs All Rights Reserved