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Sibrotuzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human FAP Therapeutic Antibody TAB-211 1mg Please Inquiry
Product Detail
Cat
TAB-211
Product Overview
Recombinant monoclonal antibody to FAP. Sibrotuzumab is a humanized monoclonal antibody intended for the treatment of cancer. It binds to FAP.
Target
FAP
Type
IgG1 - kappa
Immunogen
A synthetic peptide derived from human Fibroblast activation protein, alpha.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, WB and most other immunological methods.
CAS
216669-97-5
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human FAP (fibroblast activation protein)) (human-mouse monoclonal BIBH1 g1-chain), disulfide with human-mouse monoclonal BIBH1 k-chain, dimer
Purity
>95.0% as determined by analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Background
Antigen Description
In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
Function
dipeptidyl-peptidase activity; endopeptidase activity; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; serine-type endopeptidase activity; serine-type
Gene ID
2191
Synonyms
FAP; fibroblast activation protein, alpha; seprase; DPPIV; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; FAPA; DKFZp686G13158;
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