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Anti-FGA Protein A Scaffold

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Fibrinogen Protein A scaffold AFB-06LY 1mg Please Inquiry
Product Detail
Cat
AFB-06LY
Species Reactivity
Human
Expression Host
E. coli
Specificity
This Anti-Fibrinogen Protein A scaffold Molecule is modified with a unique C-terminal cysteine for directed single-point chemical modification, facilitating coupling to matrices. However, tail-to-tail dimers are spontaneously generated via a disulphide bridge betwe
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Background
Antigen Description
Defects in FGA are a cause of congenital afibrinogenemia (CAFBN). This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.
Note: The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
Defects in FGA are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
Function
eukaryotic cell surface binding; protein binding; protein binding, bridging; receptor binding.
Gene ID
2243
Synonyms
Fib2; MGC119422; MGC119423; MGC119425; FGA; fibri- nogen alpha chain; OTTHUMP00000197063; OTTHUMP 00000197064; fibrinogen, A alpha polypeptide
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