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Ecromeximab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human GD3 ganglioside Therapeutic Antibody TAB-131 1mg Please Inquiry
Product Detail
Cat
TAB-131
Product Overview
Recombinant monoclonal antibody to GD3 ganglioside. Ecromeximab is a chimeric monoclonal antibody being developed for the treatment of malignant melanoma.
Target
GD3 ganglioside
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
292819-64-8
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1,anti-(GD3 ganglioside) (human-mouse monoclonal KM871 g1-chain), disulfide withhuman-mouse monoclonal KM871 k-chain, dimer
Predicted N terminal
H chain: EVQLVES; L chain: DIQMTQS
Molecular Weight
145255
Purity
>95.0% as determined by analysis by RP-HPLC.
Size
1mg
Storage
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Background
Introduction
This is a chimeric monoclonal antibody being developed for the treatment of malignant melanoma.
Antigen Description
Almost all melanomas, astrocytomas, a proportion of sarcomas, a small number of carcinomas, some nevi, as well as normal melanocytes express GD3 antigen. It is one of the most important markers for malignant melanoma. Antibodies to the GD3 ganglioside can induce partial remission of tumor growth in animals as well as in Humans via enhancement of cytotoxic and proliferative response of lymphocytes.
Keywords
GD3 ganglioside
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