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codrituzumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human GPC3 Therapeutic Antibody TAB-H14 1mg Please Inquiry
Product Detail
Cat
TAB-H14
Product Overview
Recombinant Humanized antibody to Human GPC3
Type
IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS
1365267-33-9
Specificity
GPC3 (glypican 3) [Homo sapiens]
Protein Construction
"RG7686 is a first in class monoclonal humanized anti-glypican 3 antibody being developed as single agent and in combination againstmetastatic hepatocellular carcinoma. Its therapeutic activity in pre-clinical models was shown to take place via antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP)." – Roche pipelinegamma1 heavy chain (1-445) [humanized VH (Homo sapiens IGHV1-46*01 (82.70%) – (IGHD) – IGHJ5*02) [8.8.8] (1-115) – Homo sapiensIGHG1*01 (CH1 (116-213, hinge (214-228), CH2 (229-338), CH3 (339-443), CHS (444-445)) (116-445)], (218-219')-disulfide withkappa light chain (1'-219') [humanized V-KAPPA (Homo sapiens IGKV2-28*01 (86.00%) -IGKJ2*01) [11.3.9] (1'-112') – Homo sapiens IGKC*01(113'-219')]; dimer (224-224":227-227") – bisdisulfide
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Background
Antigen Description
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
Function
heparan sulfate proteoglycan binding; peptidyl-dipeptidase inhibitor activity; protein binding;
Gene ID
2719
Synonyms
GPC3; glypican 3; SDYS; glypican-3; DGSX; glypican proteoglycan 3; OCI 5; SGB; SGBS; SGBS1; secreted glypican-3; intestinal protein OCI-5; heparan sulphate proteoglycan; MXR7; OCI-5; GTR2-2;
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