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Ganitumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IGF-I Therapeutic Antibody TAB-199 1mg Please Inquiry
Product Detail
Cat
TAB-199
Product Overview
Recombinant monoclonal antibody to IGF-I. Ganitumab is a human monoclonal antibody against type 1 insulin-like growth factor receptor (IGF1R), designed for the treatment of cancers.
Target
IGF-I
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
CAS
905703-97-1
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin-likegrowth factor 1 receptor, IGF1-R, IGF-1R, CD221)], Homo sapiensmonoclonal antibody;gamma1 heavy chain (1-449) [Homo sapiens VH (IGHV4-4*02(100.00%) -(IGHD)-IGHJ3*02) [9.7.12] (1-119) -IGHG1*01 (120-449)], (222-219")-disulfide with kappa light chain (1"-219") [Homosapiens V-KAPPA (IGKV2-28*01 (95.00%) -IGKJ1*01) [11.3.9] (1"-112") -IGKC*01 (113"-219")]; (228-228"":231-231"")-bisdisulfide dimer
Predicted N terminal
H chain: QVQLQES; L chain: DVVMTQS
Molecular Weight
145700
Purity
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
Function
growth factor activity; hormone activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding;
Gene ID
3479
Synonyms
IGF1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; IGFI; IGF-I;
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