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Quilizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IGHE Therapeutic Antibody TAB-255 1mg Please Inquiry
Product Detail
Cat
TAB-255
Product Overview
Recombinant monoclonal antibody to IGHE.
Target
IGHE
Type
IgG1 - kappa
Immunogen
IgE from myelomatous human serum.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, IP, IF, FuncS, FC, Neut, ELISA and most other immunological methods.
CAS
1228538-47-3
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens IGHE connecting region (CO) M1 prime (in alternatively spliced heavy chain of membrane IgE on B cells)], humanized monoclonal antibody
Predicted N terminal
H chain: EVQLVES; L chain: DIQMTQS
Purity
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Size
1mg
Storage
4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Background
Antigen Description
IgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150 ng/ml, compared to 10 mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity. There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. IgE may play an important role in the immune system"s recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.
Gene ID
28223
Synonyms
IGHE; Immunoglobulin heavy constant epsilon;
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