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perakizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL17A Therapeutic Antibody TAB-H57 1mg Please Inquiry
Product Detail
Cat
TAB-H57
Product Overview
Recombinant Humanized (from mouse) antibody to Human IL17A. Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator.
Type
IgG1 - kappa
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
CAS
89957-37-9
Specificity
IL17A (interleukin 17A, IL-17A) [Homo sapiens]
Protein Construction
gamma1 heavy chain (1-452) [humanized VH (Homo sapiens IGHV3-7*01 (90.80%) – (IGHD) – IGHJ4*01) [8.8.15] (1-122) – Homosapiens IGHG1*01 CH2 L1.3>A (239), L1.2>A (240) (123-452)], (225-215') – disulfide withkappa light chain (1'-215') [humanized V-KAPPA (Homo sapiens IGKV1 -16*01 (82.10%) – IGKJ2*01) [6.3.10] (1'-108') – Homo sapiensIGKC*01 (109'-215')]; (231-231":234-234") – bisdisulfide dimer
Purity
>95.0% as determined by analysis by RP-HPLC.
Background
Antigen Description
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis
Function
cytokine activity;
Gene ID
3605
Synonyms
IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); IL17; CTLA8; IL-17; IL-17A;
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