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Canakinumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL1Beta Therapeutic Antibody (Ilaris) TAB-021 1mg Please Inquiry
Product Detail
Cat
TAB-021
Product Overview
Recombinant monoclonal antibody to Human IL1 beta. Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha.
Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease.
Target
IL1 beta
Type
IgG1 - kappa
Immunogen
Recombinant human ILI beta
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
CAS
914613-48-2
Trade name
ilaris
Specificity
Tested positive against native human antigen
Predicted N terminal
H Chain: EVQLVQSL Chain: EIVLTQS
Purity
Purity >95% by SDS-PAGE.
Size
1mg
Storage
Store at -20°C. Avoid multiple freeze/thaw cycles.
Background
Antigen Description
Produced by activated macrophages, IL1 stimulates thymocyte proliferation by inducing IL2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Function
cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding
Gene ID
3553
Synonyms
Catabolin; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; LAF; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin 1 beta; Preinterleukin beta; Pro interleukin 1 beta
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