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Tildrakizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL23 Therapeutic Antibody TAB-875 1mg Please Inquiry
Product Detail
Cat
TAB-875
Product Overview
Recombinant humanized (from mouse) antibody expressed in CHO binding to human IL23. Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.
Target
IL23
Type
IgG1 - kappa
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
CAS
1326244-10-3
Predicted N terminal
QVQLVQSG
Molecular Weight
144.4 kDa
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
At -20°C for one year.
Background
Introduction
Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.
Antigen Description
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Function
cytokine activity; contributes_to interleukin-23 receptor binding;
Gene ID
51561
Synonyms
IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388;
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