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Clazakizumab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL6 Therapeutic Antibody TAB-094 1mg Please Inquiry
Product Detail
Cat
TAB-094
Product Overview
Recombinant monoclonal antibody to IL6. Clazakizumab is a humanized monoclonal antibody designed for the treatment of rheumatoid arthritis.
Target
IL6
Type
IgG1 - kappa
Immunogen
Recombinant full length protein (Human).
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
CAS
1236278-28-6
Specificity
Tested positive against native human antigen.
Protein Construction
Immunoglobulin G1, anti-(human interleukin 6) (human-Oryctolagus cuniculus monoclonal BMS-945429/ALD518 heavy chain), disulfide with human-Oryctolagus cuniculus monoclonal BMS-945429/ALD518 Kappa-chain, dimer
Predicted N terminal
H Chain: EVQLVES; L Chain: DIQMTQS
Molecular Weight
145200
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Function
cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; contributes_to interleukin-6 receptor binding; interleukin-6 receptor binding;
Gene ID
3569
Synonyms
IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; IL-6;
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