Siltuximab (CAT#: TAB-212)

Datasheet

DESCRIPTION	CATALOG #	SIZE	PRICE
Anti-Human IL6 Recombinant Antibody	TAB-212	1mg	Please Inquiry

PRODUCT INFORMATION

Product Overview
Recombinant monoclonal antibody to IL-6. Siltuximab (INN) (also known as CNTO 328, Anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins) monoclonal antibody. It binds to interleukin-6. Siltuximab has been investigated for the treatment of metastatic renal cell cancer, prostate cancer, and Castleman's disease, among other types of cancer.

Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.

Protein Construction
Immunoglobulin G1-kappa, anti-[Homo sapiens interleukin 6 (IL6, IL-6)], chimeric monoclonal antibody; gamma1 heavy chain (1-449) [Mus musculus VH (IGHV5-9-4*01 -(IGHD)-IGHJ4*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01 (120-449)], (222-213")-disulfide with kappa light chain (1"-213") [Mus musculus V-KAPPA (IGKV4-55*01 –IGKJ2*01) [5.3.9] (1"-106") -Homo sapiens IGKC*01 (107"-213")]; (228-228"":231-231"")-bisdisulfide dimer

Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Antigen Description
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

Function
cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; contributes_to interleukin-6 receptor binding; interleukin-6 receptor binding;

Synonyms
IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; IL-6;

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