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Elsilimomab

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human IL6 Therapeutic Antibody TAB-239 1mg Please Inquiry
Product Detail
Cat
TAB-239
Product Overview
Recombinant monoclonal antibody to IL-6. Elsilimomab (also known as B-E8) is a mouse monoclonal antibody and an immunosuppressive drug. It (OPR-003) targets (and blocks) Interleukin-6. It has undergone a number of early stage clinical trails, e.g. for lymphoma and myeloma. It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339.
Target
IL-6
Type
IgG1
Immunogen
The details of the immunogen for this antibody are not available.
Species Reactivity
Human
Expression Host
CHO
Applications
Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
Specificity
Tested positive against native human antigen.
Purity
>95.0%. Determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Size
1mg
Storage
At -20°C for one year.
Background
Antigen Description
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
Function
cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; contributes_to interleukin-6 receptor binding; interleukin-6 receptor binding;
Gene ID
3569
Synonyms
IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor; IL-6;
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